Recent studies of the most extended clinical practice of the weight-loss drug Wegovy have uncovered new wisdom into the drug’s efficacy. 

One analysis discovered that individuals taking the drug Wegovy maintained weight failure for up to four years and fell a standard of 10% of their body importance during that time. According to another study, Wegovy users also demonstrated progress in heart health irrespective of the quantity of weight lost. 

The analyses are founded on data from the SELECT trial, which had 17,604 non-diabetics with preexisting cardiovascular conditions as well as overweight or obesity. Players were haphazardly assigned to obtain a placebo or once-weekly injections of Wegovy, which has the functional element semaglutide.

“These results have significant clinical importance,” John Deanfield, a teacher of cardiology at University College London who led the investigation, said in a press freedom. “Around half of the patients that I see in my cardiovascular exercise have levels of weight equal to those in the SELECT problem and are likely to derive advantage from taking Semaglutide on the lid of their normal level of guideline-directed care.”

University College London. ‘Weight loss’ drug semaglutide tied to better heart health.

How Wegovy Simulated Weight Loss?

Researchers tracked players for four years—twice as long as earlier studies. 

They said last month in the journal Nature that Wegovy-users continued to lose weight for a standard of 65 weeks. 

“At two years, 12% of individuals on semaglutide achieved average weight status and more than 55% no longer allowed as having obesity BMI class—both words much higher than placebo,” Donna H. Ryan, MD, an analysis writer and lecturer emerita at Pennington Biomedical Research Center, told Health.

By 208 weeks, players had decreased waist girth by a norm of about three inches, fell a standard of 10% of their body importance, and kept the importance off.

The scientists discovered that weight loss was important because of an individual’s sex, ethnicity, body size, location, age, and preexisting health needs.

“We also now have more proof for semaglutide weight loss effectiveness in older, sicker people,” Ryan said.

The investigators also found that individuals taking the drug had fewer serious negative circumstances than those taking a placebo. Yet, more individuals taking Wegovy left the analysis due to gastrointestinal signs, such as nausea and runs.

Ryan said the investigation revealed “weight loss is vital” for individuals carrying Wegovy but little less than what earlier investigation into semaglutide has revealed. “We hoped this because we were not making the amounts to top-dose in all patients and because it was not a weight loss study,” she stated.

The study didn’t explore whether individuals regain importance once they stop accepting Wegovy, as other studies have indicated. “This merits more study to comprehend weight loss supervision systems,” she said.

Heart Helps Independent of Poundage Loss

In 2023, effects from the SELECT trial showed that players had a 20% lower risk of significant negative cardiovascular events, such as heart attack and stroke. That directed the FDA to support Wegovy to decrease the risk of cardiovascular death, heart attack, and stroke in grown-ups with cardiovascular sickness and heavy or obesity (Wegovy was once only FDA-approved for chronic weight control).

However, it has been ambiguous whether Wegovy’s effect on heart health was due to its effect on weight loss or if another element was freedom.

A different analysis4 given at the European Congress on Obesity in May, however, revealed that individuals had lower odds of creating heart issues yet of the amount of weight they failed. “This means alternative tools of enhanced cardiovascular outcome further reduction in heaviness,” or body fat, the writers wrote. 

Rather than fat reduction, factors such as blood pressure, blood sugar, or inflammation could recreate a role in enhancing cardiovascular outcomes, Carlos Sanchez, MD, a specialist in cardiovascular disorder at OhioHealth Heart & Vascular, told Health.

Sue Decotiis, MD, a New York City weight-loss physician, told Health that the study’s effects are important, but a rule is that the study didn’t mention the drugs participants were carrying. “I think most were on some sort of drugs if they had cardiovascular condition,” she stated.

The participant pool was also not mixed enough to comprehend Wegovy’s impact on different peoples, according to the writers.


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